Information intended for healthcare professionals only.

This formulary decision guide was developed from content provided by Dermal Laboratories Ltd in a format developed by Guidelines in Practice.

View prescribing information and adverse event reporting here

Key points

  • Doublebase Dayleve Gel offers 12 hours protection, allowing for twice daily usage1,2
  • Doublebase Dayleve Gel is a long-lasting, highly effective emollient and protective hydrating gel for the first-line treatment and prophylaxis of dry or chapped skin conditions which may also be pruritic (itchy) or inflamed3
  • The addition of povidone significantly improves the water holding capacity of the gel4
  • With proven efficacy when used twice a day, Doublebase Dayleve Gel improves adherence to treatment, allowing for both cost and time savings
  • In two double-blind, randomised comparison studies in patients with atopic eczema, Doublebase Dayleve Gel showed significantly superior hydration compared to Zerobase® Emollient Cream1 and Diprobase® Cream2 when applied twice daily.

 

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Medicine name

Doublebase Dayleve™ Gel

Formulation

  • Doublebase Dayleve Gel contains isopropyl myristate 15% w/w and liquid paraffin 15%w/w3
  • Doublebase Dayleve Gel has a long-lasting formulation that breaks down irreversibly in the skin to deposit:
    • a high level of emollient oils
    • a high level of glycerol to help retain residual water
    • povidone, a film-forming agent, to help seal in oils and water
  • The addition of povidone significantly improves the water holding capacity of the gel.4

Indications

  • Doublebase Dayleve Gel is a long-lasting highly emollient and protective hydrating gel for regular first-line treatment and prophylaxis of dry or chapped skin conditions which may also be pruritic (itchy) or inflamed.3

Presentation and usage

  • Doublebase Dayleve Gel is a white opaque gel3
  • Its enhanced emollient gel formulation is easily absorbed into the skin, making it pleasant to apply and enhancing patient compliance
  • It is suitable for use in adults, elderly, infants, and children3
  • It should be applied to the affected areas morning and night, or as often as necessary3
  • For best results, use a few gentle strokes to smooth the gel across the skin in the same direction as hair growth3
  • Doublebase Dayleve Gel may be applied before washing, showering or having a bath to prevent further drying of the skin.3

Evidence

  • In two double-blind, randomised comparison studies in patients with atopic eczema, Doublebase Dayleve Gel showed significantly superior hydration compared to Zerobase® Emollient Cream1 and Diprobase® Cream2 when applied twice daily
  • In an ex vivo study comparing skin hydration of five different emollients, Doublebase Dayleve Gel elevated the skin hydration level by approximately 75% (compared to baseline) when measured 1 hour after application, and by approximately 30% (compared to baseline) when measured 24 hours after application.5

Cost and time economy 

  • Doublebase Dayleve Gel price: 
    • £2.65 (100 g tube)
    • £6.29 (500 g pump pack)
  • Prescription of an effective emollient helps alleviate both the condition and the extra cost associated with medicine wastage, return GP visits (£37.40 per visit), and secondary care referrals (£125.00 per outpatient appointment)6,7
  • As Doublebase Dayleve Gel is proven to be effective when used only twice a day, fewer packs are required, making it an effective and economical treatment in terms of both costs and time.

Place in therapy

  • Doublebase Dayleve Gel offers at least 12 hours protection from one application1,2
  • This allows the gel to be used just twice a day, a favourable option for patients who find it difficult to adhere to a more frequent emollient routine:
    • children attending school/nursery
    • adults leading busy lives
    • elderly needing care.

Further information

  • Further information on Doublebase Dayleve Gel is available in the healthcare professional section of the Doublebase.com website.

References

  1. Djokic-Gallagher J, Rosher P, Oliveira G, Walker J. A double-blind, randomised study comparing the skin hydration and acceptability of two emollient products in atopic eczema patients with dry skin. Dermatol Ther  2017; 7 (3): 397–406
  2. Djokic-Gallagher J, Rosher P, Walker J et al. Emollient efficacy and acceptability in the treatment of eczematous dry skin: a double-blind, randomised comparison of two UK-marketed products. 
    J Dermatolog Treat 2016; 27 (5): 461–466
  3. Dermal Laboratories Limited. Doublebase Dayleve Gel—Summary of Product Characteristics. August 2018. Available at: www.medicines.org.uk/emc/product/4705/smpc
  4. Gallagher J, Rosher P, Mohammed D et al. The role of excipient povidone in an advanced gel formulation specially designed for the treatment of dry skin conditions. Poster presented at the 23rd EADV Congress, October 2014, Amsterdam, The Netherlands
  5. Gallagher J, Rosher P, Novac O, Antonijevic M. Skin hydration comparison of five prescribed emollients. Poster presented at the 2018 AAD Annual Meeting, February 2018, San Diego, USA
  6. Personal Social Services Research Unit. Unit costs of health and social care 2017. Available at: https://kar.kent.ac.uk/65559/40/65559_rep_UCR-2017-v13finalKAR.pdf  
  7. NHS Improvement. National tariff payment system. Annex A. Available at: https://improvement.nhs.uk/resources/national-tariff/#h2-annexes  

DXXPR174/JUN19

Date of preparation: June 2019